The benefit was also found in both slow and fast metabolizers of caffeine, as well as across various types of coffee, including ground, instant and decaffeinated coffee. The investigators found that over 10 years of follow-up, coffee drinking was associated with a significantly lower risk of death, including among people who drank eight or more cups per day. The study included data on coffee consumption, as well as genetic variants related to caffeine metabolism. In the current study, the team of investigators analyzed data from a cohort of a half million people living in the United Kingdom, ranging in age from 38 to 73. However, concerns remained about the health effects of heavy coffee drinking, particularly in people with common genetic variants that affect caffeine metabolism.įor example, previous research led by Cornelis and others has suggested that variants in CYP1A2 - the gene responsible for most caffeine metabolism - may alter the association of coffee drinking with cardiovascular-related outcomes, with a higher risk for coffee drinkers who metabolize caffeine more slowly. In the past, research has generally found a link between drinking coffee and a decreased risk of major diseases, including cardiovascular disease and diabetes, as well as overall mortality. “Our study provides further evidence that drinking coffee, regular or decaf, can be part of a healthy diet and offers reassurance to coffee drinkers,” said Marilyn Cornelis, PhD, assistant professor of Preventive Medicine in the Division of Nutrition and a co-author of the study. Marilyn Cornelis, PhD, assistant professor of Preventive Medicine in the Division of Nutrition, who studies the genetics of coffee consumption, was a co-author of the study.ĭrinking coffee is associated with a lower risk of death, according to a new study published in JAMA Internal Medicine - including heavy coffee consumption, across various coffee types and among people with genetic differences that affect caffeine metabolism.
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